Its genome has a single open reading frame encoding for three structural proteins (capsid (C), membrane (M) and envelope (E)) and seven non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5).
DENV is an enveloped, positive-sense, single-stranded RNA virus that belongs to the genus Flavivirus, family Flaviviridae. Its vector, the Aedes aegypti mosquito, is widely distributed in tropical and subtropical areas around the world. It is endemic in more than 100 countries, and it is estimated that 50 million cases occur annually worldwide. The dengue virus (DENV-1–4) is the world’s most important arbovirus transmitted by infected Aedes mosquitoes. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88–2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015–2019, that were analyzed by sequencing the envelope (E) gene.
Dengue is caused by genetically distinct serotypes, DENV-1–4. Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades.
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